Altering kinetic mechanism and enzyme stability by mutagenesis of the dimer interface of glutathione reductase.

In wild-type glutathione reductase from Escherichia coli residues Val421 and Ala422 are located in an alpha-helix in a densely packed and hydrophobic region of the dimer interface, with their side chains packed against those of residues Ala422' and Val421' in the second subunit. A series o...

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Bibliographic Details
Main Authors: Bashir, A, Perham, R N, Scrutton, N S, Berry, A
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136294/
https://ncbi.nlm.nih.gov/pubmed/8526866
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