Heparin binding to platelet factor-4. An NMR and site-directed mutagenesis study: arginine residues are crucial for binding.

Native platelet factor-4 (PF4) is an asymmetrically associated, homo-tetrameric protein (70 residues/subunit) known for binding polysulphated glycosaminoglycans like heparin. PF4 N-terminal chimeric mutant M2 (PF4-M2), on the other hand, forms symmetric tetramers [Mayo, Roongta, Ilyina, Milius, Bark...

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Détails bibliographiques
Auteurs principaux: Mayo, K H, Ilyina, E, Roongta, V, Dundas, M, Joseph, J, Lai, C K, Maione, T, Daly, T J
Format: Artigo
Langue:Inglês
Publié: 1995
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136271/
https://ncbi.nlm.nih.gov/pubmed/8526843
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