Expression of phosphatidylethanolamine N-methyltransferase-2 in McArdle-RH7777 hepatoma cells inhibits the CDP-choline pathway for phosphatidylcholine biosynthesis via decreased gene expression of CTP:phosphocholine cytidylyltransferase.

Phosphatidylethanolamine N-methyltransferase-2 (PEMT2) of rat liver was expressed in McArdle-RH7777 rat hepatoma cells, which lack endogenous PEMT activity. Expression of the enzyme was confirmed by assay of PEMT activity and immunoblotting. There was no change in the amount of phosphatidylcholine i...

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Autori principali: Cui, Z, Houweling, M, Vance, D E
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1995
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136204/
https://ncbi.nlm.nih.gov/pubmed/8554542
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