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Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase.

The enzyme trypanothione reductase (TR), together with its substrate, the glutathione-spermidine conjugate trypanothione, plays an essential role in protecting parasitic trypanosomatids against oxidative stress and is a target for drug design. Here we show that a naturally occurring spermine derivat...

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Sonraí Bibleagrafaíochta
Main Authors: Ponasik, J A, Strickland, C, Faerman, C, Savvides, S, Karplus, P A, Ganem, B
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1995
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136010/
https://ncbi.nlm.nih.gov/pubmed/7487870
Clibeanna: Cuir Clib Leis
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