A mitochondrial pool of sphingomyelin is involved in TNFα-induced Bax translocation to mitochondria

We recently showed that targeting bSMase (bacterial sphingomyelinase) specifically to mitochondria caused accumulation of ceramide in mitochondria, and induced cytochrome c release and cell death [Birbes, El Bawab, Hannun and Obeid (2001) FASEB J., 15, 2669–2679]. In the present study, we investigat...

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Bibliographic Details
Main Authors: Birbes, Helene, Luberto, Chiara, Hsu, Yi-Te, El Bawab, Samer, Hannun, Yusuf A., Obeid, Lina M.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134862/
https://ncbi.nlm.nih.gov/pubmed/15516208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041627
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