The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells

The human transmembrane mucin MUC4 is aberrantly expressed in 75% of pancreatic ductal adenocarcinomas, whereas no expression is found in normal pancreas. Therefore MUC4 appears as a useful biological marker for the diagnosis of ductal adenocarcinomas. Since rat Muc4 was shown to interact with ErbB-...

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Autores principales: Fauquette, Valérie, Perrais, Michael, Cerulis, Sylvain, Jonckheere, Nicolas, Ducourouble, Marie-Paule, Aubert, Jean-Pierre, Pigny, Pascal, Seuningen, Isabelle Van
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2005
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134764/
https://ncbi.nlm.nih.gov/pubmed/15461591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040706
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