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MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis
The MUC4 membrane-bound mucin is a large O-glycoprotein involved in epithelial homeostasis. At the cancer cell surface MUC4 interacts with ErbB2 receptor via EGF domains to promote cell proliferation and migration. MUC4 is highly regarded as a therapeutic target in pancreatic cancer as it is not exp...
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| Izdano u: | Sci Rep |
|---|---|
| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6853952/ https://ncbi.nlm.nih.gov/pubmed/31723153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53099-0 |
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