Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-κB activation and interleukin-8 secretion in human bronchial epithelial cells

LPA (lysophosphatidic acid), a potent bioactive phospholipid, elicits diverse cellular responses through activation of the G-protein-coupled receptors LPA(1)–LPA(4). LPA-mediated signalling is partially regulated by LPPs (lipid phosphate phosphatases; LPP-1, -2 and -3) that belong to the phosphatase...

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Autores principales: Zhao, Yutong, Usatyuk, Peter V., Cummings, Rhett, Saatian, Bahman, He, Donghong, Watkins, Tonya, Morris, Andrew, Spannhake, Ernst Wm., Brindley, David N., Natarajan, Viswanathan
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2005
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134721/
https://ncbi.nlm.nih.gov/pubmed/15461590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041160
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