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Phosphatidylinositol 3,4,5-trisphosphate and Ca(2+)/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action
RGS (regulators of G-protein signalling) are a diverse group of proteins, which accelerate intrinsic GTP hydrolysis on heterotrimeric G-protein α subunits. They are involved in the control of a physiological behaviour known as ‘relaxation’ of G-protein-gated K(+) channels in cardiac myocytes. The GT...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Portland Press Ltd.
2004
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1134674/ https://ncbi.nlm.nih.gov/pubmed/15324308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040404 |
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