Phosphatidylinositol 3,4,5-trisphosphate and Ca(2+)/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action

RGS (regulators of G-protein signalling) are a diverse group of proteins, which accelerate intrinsic GTP hydrolysis on heterotrimeric G-protein α subunits. They are involved in the control of a physiological behaviour known as ‘relaxation’ of G-protein-gated K(+) channels in cardiac myocytes. The GT...

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Main Authors: Ishii, Masaru, Fujita, Satoru, Yamada, Mitsuhiko, Hosaka, Yukio, Kurachi, Yoshihisa
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2004
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134674/
https://ncbi.nlm.nih.gov/pubmed/15324308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040404
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