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In brain mitochondria the branched-chain fatty acid phytanic acid impairs energy transduction and sensitizes for permeability transition

Phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) accumulates at high levels throughout the body in the adult form of Refsum disease, a peroxisomal genetic disorder. However, it is still unclear why increased levels of phytanic acid have cytotoxic effects. In the present study, we examined the...

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Bibliografski detalji
Glavni autori: SCHöNFELD, Peter, Kahlert, Stefan, Reiser, Georg
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2004
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134050/
https://ncbi.nlm.nih.gov/pubmed/15198638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040583
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