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Molecular modelling of the nucleotide-binding domain of Wilson's disease protein: location of the ATP-binding site, domain dynamics and potential effects of the major disease mutations

WNDP (Wilson's disease protein) is a copper-transporting ATPase that plays an essential role in human physiology. Mutations in WNDP result in copper accumulation in tissues and cause a severe hepato-neurological disorder known as Wilson's disease. Several mutations were surmised to affect...

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Bibliografische gegevens
Hoofdauteurs: Efremov, Roman G., Kosinsky, Yuri A., Nolde, Dmitry E., Tsivkovskii, Ruslan, Arseniev, Alexander S., Lutsenko, Svetlana
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Portland Press Ltd. 2004
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133942/
https://ncbi.nlm.nih.gov/pubmed/15147237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040326
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