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Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates

Activated phagocytes release the haem enzyme MPO (myeloperoxidase) and also generate superoxide radicals (O(2)(•−)), and hence H(2)O(2), via an oxidative burst. Reaction of MPO with H(2)O(2) in the presence of chloride ions generates HOCl (the physiological mixture of hypochlorous acid and its anion...

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Bibliografiske detaljer
Main Authors: Rees, Martin D., Hawkins, Clare L., Davies, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133775/
https://ncbi.nlm.nih.gov/pubmed/15078224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040148
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