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Protein kinase A modulates Ca(2+)- and protein kinase C-dependent amylase release in permeabilized rat pancreatic acini.

The role of protein kinase A (PKA) in the release of amylase from permeabilized pancreatic acini was investigated. Addition of cyclic AMP (cAMP) to permeabilized acini resulted in a potentiation of Ca(2+)-dependent amylase release, shifting the Ca2+ dose/response curve leftwards. As with protein kin...

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Библиографические подробности
Главные авторы: O'Sullivan, A J, Jamieson, J D
Формат: Artigo
Язык:Inglês
Опубликовано: 1992
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133179/
https://ncbi.nlm.nih.gov/pubmed/1280101
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