Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.

Pyrazole, cobalt and phenobarbital increase the activity of coumarin 7-hydroxylase (COH) in mouse liver. To study the mechanism of this increase, we measured the expression of the cytochrome P-450 2a-4/5 (Cyp2a-4/5) complex, which mediates testosterone 15 alpha-hydroxylase and COH activities, as a f...

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Auteurs principaux: Hahnemann, B, Salonpää, P, Pasanen, M, Mäenpää, J, Honkakoski, P, Juvonen, R, Lang, M A, Pelkonen, O, Raunio, H
Format: Artigo
Langue:Inglês
Publié: 1992
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133053/
https://ncbi.nlm.nih.gov/pubmed/1520280
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