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Altered expression of cytochrome P-450 mRNAs, and potentially of other transcripts encoding key hepatic functions, are triggered during the isolation of rat hepatocytes.

The abundance of 12 cytochrome P-450 (CYP) mRNAs was quantified in the caudate lobe of rat livers before dissociation of the organ into single cells by perfusion with 0.025% (w/v) collagenase. Comparison of the initial abundance of CYP-1A1, -1A2, -2A subfamily, -2B1/2, -2C7, -2C11, -2D subfamily, -2...

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Bibliografiske detaljer
Main Authors: Padgham, C R, Paine, A J
Format: Artigo
Sprog:Inglês
Udgivet: 1993
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1132219/
https://ncbi.nlm.nih.gov/pubmed/8435060
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