A recombinant hybrid anaphylatoxin with dual C3a/C5a activity.

By site-directed mutagenesis of a human complement factor C5a cDNA clone, we have designed a hybrid anaphylatoxin in which three amino acid residues in the C-terminal sequence of human C5a were exchanged to create the native C-terminal human C3a (hC3a) sequence Leu-Gly-Leu-Ala-Arg. This hybrid anaph...

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Dettagli Bibliografici
Autori principali: Bautsch, W, Kretzschmar, T, Stühmer, T, Kola, A, Emde, M, Köhl, J, Klos, A, Bitter-Suermann, D
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1992
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1132107/
https://ncbi.nlm.nih.gov/pubmed/1445269
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