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Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing
We show that in budding yeast large rDNA deletions arise frequently and cause an increase in telomeric and mating-type gene silencing proportional to repeat loss. Paradoxically, this increase in silencing is correlated with a highly specific down-regulation of SIR2, which encodes a deacetylase enzym...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1132006/ https://ncbi.nlm.nih.gov/pubmed/15905408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.340205 |
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