Secondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymes

We have investigated the relative merits of two commonly used methods for target site selection for ribozymes: secondary structure prediction (MFold program) and in vitro accessibility assays. A total of eight methylated ribozymes with DNA arms were synthesized and analyzed in a transient co-transfe...

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Dades bibliogràfiques

Publicat a:	Nucleic Acids Res
Autors principals:	Amarzguioui, Mohammed, Brede, Gaute, Babaie, Eshrat, Grøtli, Morten, Sproat, Brian, Prydz, Hans
Format:	Artigo
Idioma:	Inglês
Publicat:	Oxford University Press 2000
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC113158/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11058107/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.21.4113
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