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Stabilization of the U5-leader stem in the HIV-1 RNA genome affects initiation and elongation of reverse transcription

Reverse transcription of the Human Immunodeficiency Virus type I (HIV-1) RNA genome is primed by a cellular tRNA–lys3 molecule that binds to the primer binding site (PBS). The PBS is predicted to be part of an extended RNA structure, consisting of a small U5-PBS hairpin and a large U5-leader stem. I...

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Détails bibliographiques
Auteurs principaux: Beerens, Nancy, Groot, Fedde, Berkhout, Ben
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2000
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC113157/
https://ncbi.nlm.nih.gov/pubmed/11058109
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