Dependence of Echovirus 9 on the Enterovirus RNA Replication Inhibitor 2-(α-Hydroxybenzyl)-Benzimidazole Maps to Nonstructural Protein 2C

HBB [2-(α-hydroxybenzyl)-benzimidazole] selectively inhibits RNA synthesis of most enteroviruses. However, isolation of HBB-dependent variants is possible. Sequence analysis and characterization of recombinant viruses revealed that HBB dependence maps to the nonstructural protein 2C. A single point...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Hadaschik, Dirk, Klein, Marcus, Zimmermann, Holger, Eggers, Hans J., Nelsen-Salz, Birgit
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC113111/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10559374/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.12.10536-10539.1999
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