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Peptidyldiazomethanes. A novel mechanism of interaction with prolyl endopeptidase.

Peptidyldiazomethanes with proline in the P1 position were found to be competitive slow-binding inhibitors of prolyl endopeptidase. Progress-curve experiments monitoring the increase in the degree of inhibition with time indicated that the kinetic mechanism involved an initial complex that isomerize...

詳細記述

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書誌詳細
主要な著者: Stone, S R, Rennex, D, Wikstrom, P, Shaw, E, Hofsteenge, J
フォーマット: Artigo
言語:Inglês
出版事項: 1992
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1130967/
https://ncbi.nlm.nih.gov/pubmed/1590775
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