A Polymorphism in the Regulatory Region of the CC-Chemokine Receptor 5 Gene Influences Perinatal Transmission of Human Immunodeficiency Virus Type 1 to African-American Infants

There are natural mutations in the coding and noncoding regions of the human immunodeficiency virus type 1 (HIV-1) CC-chemokine coreceptor 5 (CCR5) and in the related CCR2 protein (the CCR2-64I mutation). Individuals homozygous for the CCR5-Δ32 allele, which prevents CCR5 expression, strongly resist...

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Hauptverfasser: Kostrikis, Leondios G., Neumann, Avidan U., Thomson, Bruce, Korber, Bette T., McHardy, Paul, Karanicolas, Rose, Deutsch, Lisa, Huang, Yaoxing, Lew, Judy F., McIntosh, Kenneth, Pollack, Henry, Borkowsky, William, Spiegel, Hans M. L., Palumbo, Paul, Oleske, James, Bardeguez, Arlene, Luzuriaga, Katherine, Sullivan, John, Wolinsky, Steven M., Koup, Richard A., Ho, David D., Moore, John P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC113080/
https://ncbi.nlm.nih.gov/pubmed/10559343
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