A Polymorphism in the Regulatory Region of the CC-Chemokine Receptor 5 Gene Influences Perinatal Transmission of Human Immunodeficiency Virus Type 1 to African-American Infants

There are natural mutations in the coding and noncoding regions of the human immunodeficiency virus type 1 (HIV-1) CC-chemokine coreceptor 5 (CCR5) and in the related CCR2 protein (the CCR2-64I mutation). Individuals homozygous for the CCR5-Δ32 allele, which prevents CCR5 expression, strongly resist...

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Detalhes bibliográficos
Main Authors: Kostrikis, Leondios G., Neumann, Avidan U., Thomson, Bruce, Korber, Bette T., McHardy, Paul, Karanicolas, Rose, Deutsch, Lisa, Huang, Yaoxing, Lew, Judy F., McIntosh, Kenneth, Pollack, Henry, Borkowsky, William, Spiegel, Hans M. L., Palumbo, Paul, Oleske, James, Bardeguez, Arlene, Luzuriaga, Katherine, Sullivan, John, Wolinsky, Steven M., Koup, Richard A., Ho, David D., Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC113080/
https://ncbi.nlm.nih.gov/pubmed/10559343
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