Efficient Processing of the Immunodominant, HLA-A*0201-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitope despite Multiple Variations in the Epitope Flanking Sequences

Immune escape from cytotoxic T-lymphocyte (CTL) responses has been shown to occur not only by changes within the targeted epitope but also by changes in the flanking sequences which interfere with the processing of the immunogenic peptide. However, the frequency of such an escape mechanism has not b...

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Detalhes bibliográficos
Main Authors: Brander, Christian, Yang, Otto O., Jones, Norman G., Lee, Yun, Goulder, Philip, Johnson, R. Paul, Trocha, Alicja, Colbert, David, Hay, Christine, Buchbinder, Susan, Bergmann, Cornelia C., Zweerink, Hans J., Wolinsky, Steven, Blattner, William A., Kalams, Spyros A., Walker, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC113072/
https://ncbi.nlm.nih.gov/pubmed/10559335
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