Synthesis and characterization of a high-affinity photoactivatable analogue of thyrotropin-releasing hormone.

An analogue of thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2), i.e. pGlu-His-ProNH-(CH2)6-(4-azidosalicylamide) (TRH-ASA), has been synthesized and, in a radioiodinated form (TRH-IASA), characterized and used as a photoaffinity reagent to label the TRH receptor on rat pituitary GH4C1 cells. TR...

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Bibliographic Details
Main Authors: Brady, K D, Tashjian, A H
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1130658/
https://ncbi.nlm.nih.gov/pubmed/1310004
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