Characterization of the structure and conformation of platelet-derived growth factor-BB (PDGF-BB) and proteinase-resistant mutants of PDGF-BB expressed in Saccharomyces cerevisiae.

A detailed biophysical study of the secondary and tertiary structures of recombinant platelet-derived growth factor (PDGF)-BB produced in yeast has been carried out. The secondary structure of the molecule is composed of 54% beta-sheet with less than 5% ordered helix. The single tryptophan residue h...

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Bibliographic Details
Main Authors:	Craig, S, Clements, J M, Cook, A L, Dryden, D T, Green, D R, Heremans, K, Kirwin, P M, Price, M J, Fallon, A
Format:	Artigo
Language:	Inglês
Published:	1992
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1130641/ https://ncbi.nlm.nih.gov/pubmed/1731769
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Characterization of the structure and conformation of platelet-derived growth factor-BB (PDGF-BB) and proteinase-resistant mutants of PDGF-BB expressed in Saccharomyces cerevisiae.

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