Purification and analysis of proteinase-resistant mutants of recombinant platelet-derived growth factor-BB exhibiting improved biological activity.

Recombinant platelet-derived growth factor (PDGF)-BB was expressed and secreted from yeast in order to study the structure-function relationships of this mitogen. A simple purification scheme has been developed which yields greater than 95% pure PDGF-BB. Analysis of this recombinant PDGF-BB shows pa...

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Bibliographic Details
Main Authors: Cook, A L, Kirwin, P M, Craig, S, Bawden, L J, Green, D R, Price, M J, Richardson, S J, Fallon, A, Drummond, A H, Edwards, R M
Format: Artigo
Language:Inglês
Published: 1992
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1130640/
https://ncbi.nlm.nih.gov/pubmed/1731768
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