Impact of tumour necrosis factor-alpha and interferon-gamma on tetrahydrobiopterin synthesis in murine fibroblasts and macrophages.

Tumour necrosis factor-alpha causes an up to 30-fold induction of GTP cyclohydrolase I (EC 3.5.4.16) activity in murine dermal fibroblasts in a dose-dependent manner. Owing to the high constitutive activities of 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase (EC 1.1.1.153), this poten...

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Sonraí Bibleagrafaíochta
Main Authors: Werner, E R, Werner-Felmayer, G, Fuchs, D, Hausen, A, Reibnegger, G, Yim, J J, Wachter, H
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1991
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1130511/
https://ncbi.nlm.nih.gov/pubmed/1764035
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