The V Protein of Simian Virus 5 Inhibits Interferon Signalling by Targeting STAT1 for Proteasome-Mediated Degradation

To replicate in vivo, viruses must circumvent cellular antiviral defense mechanisms, including those induced by the interferons (IFNs). Here we demonstrate that simian virus 5 (SV5) blocks IFN signalling in human cells by inhibiting the formation of the IFN-stimulated gene factor 3 and gamma-activat...

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Bibliographic Details
Main Authors: Didcock, L., Young, D. F., Goodbourn, S., Randall, R. E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC113042/
https://ncbi.nlm.nih.gov/pubmed/10559305
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