Mutations in the DG Loop of Adenovirus Type 5 Fiber Knob Protein Abolish High-Affinity Binding to Its Cellular Receptor CAR

The amino acid residues in adenovirus type 5 (Ad5) fiber that interact with its cellular receptor, the coxsackie B virus and Ad receptor (CAR), have not been defined. To investigate this, multiple mutations were constructed in the region between residues 479 and 497 in Ad5 fiber (β-strands E and F a...

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Bibliographic Details
Main Authors: Kirby, Ian, Davison, Elizabeth, Beavil, Andrew J., Soh, Cecilia P. C., Wickham, Thomas J., Roelvink, Peter W., Kovesdi, Imre, Sutton, Brian J., Santis, George
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112985/
https://ncbi.nlm.nih.gov/pubmed/10516059
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