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Detection of Bovine Spongiform Encephalopathy-Specific PrP(Sc) by Treatment with Heat and Guanidine Thiocyanate

The conversion of a ubiquitous cellular protein (PrP(C)), an isoform of the prion protein (PrP), to the pathology-associated isoform PrP(Sc) is one of the hallmarks of transmissible spongiform encephalopathies such as bovine spongiform encephalopathy (BSE). Accumulation of PrP(Sc) has been used to d...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Meyer, Rudolf K., Oesch, Bruno, Fatzer, Rosmarie, Zurbriggen, Andreas, Vandevelde, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC112973/
https://ncbi.nlm.nih.gov/pubmed/10516047
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