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African Swine Fever Virus dUTPase Is a Highly Specific Enzyme Required for Efficient Replication in Swine Macrophages

The African swine fever virus (ASFV) gene E165R, which is homologous to dUTPases, has been characterized. A multiple alignment of dUTPases showed the conservation in ASFV dUTPase of the motifs that define this protein family. A biochemical analysis of the purified recombinant enzyme showed that the...

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Udgivet i:J Virol
Principais autores: Oliveros, Mariano, García-Escudero, Ramón, Alejo, Alí, Viñuela, Eladio, Salas, María L., Salas, José
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1999
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112924/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10515998/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.11.8934-8943.1999
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