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Latent Adeno-Associated Virus Infection Elicits Humoral but Not Cell-Mediated Immune Responses in a Nonhuman Primate Model

Latent infection with wild-type (wt) adeno-associated virus (AAV) was studied in rhesus macaques, a species that is a natural host for AAV and that has some homology to humans with respect to the preferred locus for wt AAV integration. Each of eight animals was infected with an inoculum of 10(10) IU...

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Udgivet i:J Virol
Principais autores: Hernandez, Yosbani J., Wang, Jianming, Kearns, William G., Loiler, Scott, Poirier, Amy, Flotte, Terence R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1999
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112875/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10482608/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.10.8549-8558.1999
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