Protection by Live, Attenuated Simian Immunodeficiency Virus against Heterologous Challenge

We examined the ability of a live, attenuated deletion mutant of simian immunodeficiency virus (SIV), SIVmac239Δ3, which is missing nef and vpr genes, to protect against challenge by heterologous strains SHIV89.6p and SIVsmE660. SHIV89.6p is a pathogenic, recombinant SIV in which the envelope gene h...

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Main Authors: Wyand, Michael S., Manson, Kelledy, Montefiori, David C., Lifson, Jeffrey D., Johnson, R. Paul, Desrosiers, Ronald C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1999
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC112853/
https://ncbi.nlm.nih.gov/pubmed/10482586
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