Lack of Interleukin-6 (IL-6) Enhances Susceptibility to Infection but Does Not Alter Latency or Reactivation of Herpes Simplex Virus Type 1 in IL-6 Knockout Mice

The ability of the pleotropic, proinflammatory cytokine interleukin-6 (IL-6) to affect the replication, latency, and reactivation of herpes simplex virus type 1 (HSV-1) in cell culture and in IL-6 knockout (KO) mice was studied. In initial studies, we found no effect of exogenous IL-6, monoclonal an...

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Pubblicato in:	J Virol
Autori principali:	LeBlanc, Rona A., Pesnicak, Lesley, Cabral, Erik S., Godleski, Matthew, Straus, Stephen E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112831/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10482564/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.10.8145-8151.1999
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