Attenuated, Replication-Competent Herpes Simplex Virus Type 1 Mutant G207: Safety Evaluation of Intracerebral Injection in Nonhuman Primates

This study examined the safety of intracerebral inoculation of G207, an attenuated, replication-competent herpes simplex virus type 1 (HSV-1) recombinant, in nonhuman primates. Sixteen New World owl monkeys (Aotus nancymae [karyotype 1, formerly believed to be A. trivirgatus]), known for their exqui...

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Detalhes bibliográficos
Main Authors: Hunter, William D., Martuza, Robert L., Feigenbaum, Frank, Todo, Tomoki, Mineta, Toshihiro, Yazaki, Takahito, Toda, Masahiro, Newsome, Joseph T., Platenberg, R. Craig, Manz, Herbert J., Rabkin, Samuel D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC112710/
https://ncbi.nlm.nih.gov/pubmed/10400723
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