Generation of an Adenovirus Vector Lacking E1, E2a, E3, and All of E4 except Open Reading Frame 3

Toxicity and immunity associated with adenovirus backbone gene expression is an important hurdle to overcome for successful gene therapy. Recent efforts to improve adenovirus vectors for in vivo use have focused on the sequential deletion of essential early genes. Adenovirus vectors have been constr...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Gorziglia, Mario I., Lapcevich, Claudia, Roy, Soumitra, Kang, Qiang, Kadan, Mike, Wu, Vivian, Pechan, Peter, Kaleko, Mike
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Gene Therapy
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112666/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10364357/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.7.6048-6055.1999
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