Shift of Clinical Human Immunodeficiency Virus Type 1 Isolates from X4 to R5 and Prevention of Emergence of the Syncytium-Inducing Phenotype by Blockade of CXCR4

The emergence of X4 human immunodeficiency virus type 1 (HIV-1) strains in HIV-1-infected individuals has been associated with CD4(+) T-cell depletion, HIV-mediated CD8(+) cell apoptosis, and an impaired humoral response. The bicyclam AMD3100, a selective antagonist of CXCR4, selected for the outgro...

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Hauptverfasser: Esté, José A., Cabrera, Cecilia, Blanco, Julià, Gutierrez, Arantxa, Bridger, Gary, Henson, Geoffrey, Clotet, Bonaventura, Schols, Dominique, De Clercq, Erik
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC112615/
https://ncbi.nlm.nih.gov/pubmed/10364306
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