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Use of Major Histocompatibility Complex Class I/Peptide/β2M Tetramers To Quantitate CD8(+) Cytotoxic T Lymphocytes Specific for Dominant and Nondominant Viral Epitopes in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys

To evaluate the impact of the diversity of antigen recognition by T lymphocytes on disease pathogenesis, we must be able to identify and analyze simultaneously cytotoxic T-lymphocyte (CTL) responses specific for multiple viral epitopes. Many of the studies of the role of CD8(+) CTLs in AIDS pathogen...

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Udgivet i:J Virol
Principais autores: Egan, Michael A., Kuroda, Marcelo J., Voss, Gerald, Schmitz, Jörn E., Charini, William A., Lord, Carol I., Forman, Meryl A., Letvin, Norman L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1999
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112603/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10364294/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.7.5466-5472.1999
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