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p53-Independent and -Dependent Requirements for E1B-55K in Adenovirus Type 5 Replication
The adenovirus type 5 mutant dl1520 was engineered previously to be completely defective for E1B-55K functions. Recently, this mutant (also known as ONYX-015) has been suggested to replicate preferentially in p53(−) and some p53(+) tumor cell lines but to be attenuated in primary cultured cells (C....
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology
1999
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC112589/ https://ncbi.nlm.nih.gov/pubmed/10364280 |
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