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RGD Inclusion in the Hexon Monomer Provides Adenovirus Type 5-Based Vectors with a Fiber Knob-Independent Pathway for Infection

Hypervariable region 5 (HVR5) is a hydrophilic, serotypically nonconserved loop of the hexon monomer which extrudes from the adenovirus (Ad) capsid. We have replaced the HVR5 sequence of Ad5 with that of heterologous peptides and studied their effects on virus viability and peptide accessibility. A...

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Detalhes bibliográficos
Main Authors: Vigne, Emmanuelle, Mahfouz, Irene, Dedieu, Jean-Francois, Brie, Anne, Perricaudet, Michel, Yeh, Patrice
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC112562/
https://ncbi.nlm.nih.gov/pubmed/10233980
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