Highly Efficient Induction of Protective Immunity by a Vaccinia Virus Vector Defective in Late Gene Expression

Vaccinia viruses defective in the essential gene coding for the enzyme uracil DNA glycosylase (UDG) do not undergo DNA replication and do not express late genes in wild-type cells. A UDG-deficient vaccinia virus vector carrying the tick-borne encephalitis (TBE) virus prM/E gene, termed vD4-prME, was...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Holzer, G. W., Remp, G., Antoine, G., Pfleiderer, M., Enzersberger, O. M., Emsenhuber, W., Hämmerle, T., Gruber, F., Urban, C., Falkner, F. G., Dorner, F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112493/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10233911/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.6.4536-4542.1999
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