Lack of Shielding of Primer Binding Site Silencer-Mediated Repression of an Internal Promoter in a Retrovirus Vector by the Putative Insulators scs, BEAD-1, and HS4

A major determinant for transcriptional incompetence of murine leukemia virus (MLV) and MLV-derived vectors in embryonal cells is located at the proline primer binding site (PBS). The mechanism of silencing is unknown, yet the effect is capable of spreading to adjacent promoters. Based on a retrovir...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Modin, Charlotte, Pedersen, Finn Skou, Duch, Mogens
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Gene Therapy
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112452/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11090169/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.24.11697-11707.2000
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