High-Titer, Wild-Type Free Recombinant Adeno-Associated Virus Vector Production Using Intron-Containing Helper Plasmids

Recombinant adeno-associated virus (rAAV) is capable of directing long-term, high-level transgene expression without destructive cell-mediated immune responses. However, traditional packaging methods for rAAV vectors are generally inefficient and contaminated with replication-competent AAV (rcAAV) p...

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Bibliographic Details
Main Authors: Cao, Lei, Liu, Yuhong, During, Matthew J., Xiao, Weidong
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112424/
https://ncbi.nlm.nih.gov/pubmed/11090141
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