Functional Heterogeneity and High Frequencies of Cytomegalovirus-Specific CD8(+) T Lymphocytes in Healthy Seropositive Donors

Human cytomegalovirus (HCMV) infection is largely asymptomatic in the immunocompetent host, but remains a major cause of morbidity in immunosuppressed individuals. Using the recently described technique of staining antigen-specific CD8(+) T cells with peptide-HLA tetrameric complexes, we have demons...

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Bibliographic Details
Main Authors: Gillespie, Geraldine M. A., Wills, Mark R., Appay, Victor, O'Callaghan, Chris, Murphy, Mike, Smith, Neil, Sissons, Patrick, Rowland-Jones, Sarah, Bell, John I., Moss, Paul A. H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112348/
https://ncbi.nlm.nih.gov/pubmed/10933725
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