E2F Proteins Are Posttranslationally Modified Concomitantly with a Reduction in Nuclear Binding Activity in Cells Infected with Herpes Simplex Virus 1

The transition from G(1) to S phase in the cell cycle requires sequential activation of cyclin-dependent kinase 4 (cdk4) and cdk2, which phosphorylate the retinoblastoma protein, causing the release of E2F. Free E2F upregulates the transcription of genes involved in S phase and cell cycle progressio...

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Bibliographic Details
Main Authors: Advani, Sunil J., Weichselbaum, Ralph R., Roizman, Bernard
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112314/
https://ncbi.nlm.nih.gov/pubmed/10933691
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