Mechanism of Rep-Mediated Adeno-Associated Virus Origin Nicking
The single-stranded adeno-associated virus type 2 (AAV) genome is flanked by terminal repeats (TRs) that fold back on themselves to form hairpinned structures. During AAV DNA replication, the TRs are nicked by the virus-encoded Rep proteins at the terminal resolution site (trs). This origin function...
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| Publicado no: | J Virol |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112305/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10933682/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.17.7762-7771.2000 |
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