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Mechanism of Rep-Mediated Adeno-Associated Virus Origin Nicking

The single-stranded adeno-associated virus type 2 (AAV) genome is flanked by terminal repeats (TRs) that fold back on themselves to form hairpinned structures. During AAV DNA replication, the TRs are nicked by the virus-encoded Rep proteins at the terminal resolution site (trs). This origin function...

詳細記述

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書誌詳細
主要な著者: Brister, J. Rodney, Muzyczka, Nicholas
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2000
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC112305/
https://ncbi.nlm.nih.gov/pubmed/10933682
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