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Mechanism of Rep-Mediated Adeno-Associated Virus Origin Nicking

The single-stranded adeno-associated virus type 2 (AAV) genome is flanked by terminal repeats (TRs) that fold back on themselves to form hairpinned structures. During AAV DNA replication, the TRs are nicked by the virus-encoded Rep proteins at the terminal resolution site (trs). This origin function...

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Bibliografiske detaljer
Main Authors: Brister, J. Rodney, Muzyczka, Nicholas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC112305/
https://ncbi.nlm.nih.gov/pubmed/10933682
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