Inhibition of Human Immunodeficiency Virus Type 1 Replication in Primary CD4(+) T Lymphocytes, Monocytes, and Dendritic Cells by Cytotoxic T Lymphocytes

We demonstrate that human immunodeficiency virus type 1 (HIV-1)-specific CD8(+) cytotoxic T lymphocytes (CTL) suppress HIV-1 replication in primary lymphocytes, monocytes, and dendritic cells individually. Viral inhibition is significantly diminished in lymphocyte-dendritic cell clusters, suggesting...

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Bibliographic Details
Main Authors: Severino, Michael E., Sipsas, Nikolaos V., Nguyen, Phuong Thi, Kalams, Spyros A., Walker, Bruce D., Johnson, R. Paul, Yang, Otto O.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112184/
https://ncbi.nlm.nih.gov/pubmed/10864688
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