Replacement of the Ectodomains of the Hemagglutinin-Neuraminidase and Fusion Glycoproteins of Recombinant Parainfluenza Virus Type 3 (PIV3) with Their Counterparts from PIV2 Yields Attenuated PIV2 Vaccine Candidates

We sought to develop a live attenuated parainfluenza virus type 2 (PIV2) vaccine strain for use in infants and young children, using reverse genetic techniques that previously were used to rapidly produce a live attenuated PIV1 vaccine candidate. The PIV1 vaccine candidate, designated rPIV3-1cp45, w...

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Autors principals: Tao, Tao, Skiadopoulos, Mario H., Davoodi, Fatemeh, Riggs, Jeffrey M., Collins, Peter L., Murphy, Brian R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC112153/
https://ncbi.nlm.nih.gov/pubmed/10864657
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