Human Papillomavirus Type 16 E6 Induces Self-Ubiquitination of the E6AP Ubiquitin-Protein Ligase

The E6 protein of the high-risk human papillomaviruses (HPVs) and the cellular ubiquitin-protein ligase E6AP form a complex which causes the ubiquitination and degradation of p53. We show here that HPV16 E6 promotes the ubiquitination and degradation of E6AP itself. The half-life of E6AP is shorter...

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Bibliographic Details
Main Authors: Kao, Wynn H., Beaudenon, Sylvie L., Talis, Andrea L., Huibregtse, Jon M., Howley, Peter M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Transformation and Oncogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112148/
https://ncbi.nlm.nih.gov/pubmed/10864652
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